RFA-AI-27-019: Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)

Sponsor: NIH
Internal Deadline: 05/21/2026
Institutional Submission Limit: varies
Program Website

The purpose of this notice of funding opportunity (NOFO) is to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal of this research is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines.

This initiative will support a synergistic and cross-disciplinary effort to generate, coordinate, and integrate data from human clinical samples to address critical questions in influenza immune "imprinting" research. The study findings will be made available to the public as rapidly as possible. The clinical data and biological samples collected from the cohort(s) are expected to be available for sharing and use by the scientific community to continue research in this important field, as appropriate and consistent with achieving the goals of the program.

 

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

Submission Process

Limited submissions MUST be coordinated with the Office of the Vice President for Research.

If interested in applying for this opportunity, please combine the following items into a single PDF and email to resdev@mailbox.sc.edu by 5pm on the INTERNAL DEADLINE above:

• Cover page with grant program name & number (if applicable) to which you are applying, your project title, PI (name, department/unit, & email), and list of co-PIs/key collaborators (name & department/unit)
• a two-page project abstract addressing key components/criteria for this specific grant program
• a 2-3 page CV/biosketch for the PI (SCiENcv preferred)